Title : Increased negative superhelical density in vivo enhances the genetic instability of triplet repeat sequences.

Pub. Date : 2005 Nov 11

PMID : 16166072






1 Functional Relationships(s)
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1 The capacity of these DNA tracts to undergo deletions-expansions was explored with three genetic-biochemical approaches including first, the utilization of topoisomerase I and/or DNA gyrase mutants, second, the specific inhibition of DNA gyrase by novobiocin, and third, the genetic removal of the HU protein, thus lowering the negative supercoil density (-sigma). Novobiocin DNA topoisomerase II alpha Homo sapiens