Pub. Date : 2005 Nov 4
PMID : 16165089
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Blockade of geranylgeranylation by rosuvastatin upregulates eNOS expression in human venous endothelial cells. | Rosuvastatin Calcium | nitric oxide synthase 3 | Homo sapiens |
| 2 | In a concentration-dependent manner, rosuvastatin upregulated eNOS mRNA and protein expression. | Rosuvastatin Calcium | nitric oxide synthase 3 | Homo sapiens |
| 3 | The effects on eNOS expression mediated through rosuvastatin could be reversed by treatment with mevalonate indicating inhibition of HMG-CoA reductase as the underlying mechanism. | Rosuvastatin Calcium | nitric oxide synthase 3 | Homo sapiens |
| 4 | Treatment with geranylgeranylpyrophosphate, but not farnesylpyrophosphate, reversed the increase of eNOS expression induced by rosuvastatin. | Rosuvastatin Calcium | nitric oxide synthase 3 | Homo sapiens |