Pub. Date : 2005 May-Jun
PMID : 16158930
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we characterized one of these compounds, termed tetrandrine, and evaluated its reversal activity on P-gp-mediated drug resistance to paclitaxel in vitro and in vivo. | tetrandrine | phosphoglycolate phosphatase | Homo sapiens |
| 2 | MATERIALS AND METHODS: Using the human MDR tumor cell line KBv200 and its drug sensitive parental cell line, the reversal activity of tetrandrine on P-gp-mediated resistance to paclitaxel and docetaxel were determined by MTT and other in vitro drug evaluation assays. | tetrandrine | phosphoglycolate phosphatase | Homo sapiens |
| 3 | In addition, accumulation and efflux studies with [3H]-paclitaxel indicated that tetrandrine increases the intracellular accumulation of [3H]-paclitaxel in MDR cells through inhibition of P-gp-mediated drug efflux. | tetrandrine | phosphoglycolate phosphatase | Homo sapiens |
| 4 | CONCLUSION: The present in vitro and in vivo studies demonstrated that tetrandrine possesses potent and specific activity in reversing P-gp-mediated drug resistance. | tetrandrine | phosphoglycolate phosphatase | Homo sapiens |