Title : Combining prenylation inhibitors causes synergistic cytotoxicity, apoptosis and disruption of RAS-to-MAP kinase signalling in multiple myeloma cells.

Pub. Date : 2005 Sep

PMID : 16156861






1 Functional Relationships(s)
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1 However, combinations of FTI and GGTI or lovastatin were found to synergistically inhibit MM cell proliferation, migration, K- and N-RAS processing, RAS-to-mitogen-activated protein kinase signalling and to induce apoptosis. Lovastatin KRAS proto-oncogene, GTPase Homo sapiens