Title : Modulatory effects of plant phenols on human multidrug-resistance proteins 1, 4 and 5 (ABCC1, 4 and 5).

Pub. Date : 2005 Sep

PMID : 16156793






3 Functional Relationships(s)
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1 This study investigates the interactions of six common polyphenols; quercetin, silymarin, resveratrol, naringenin, daidzein and hesperetin with the multidrug-resistance-associated proteins, MRP1, MRP4 and MRP5. Quercetin ATP binding cassette subfamily C member 1 Homo sapiens
2 Also, both quercetin and silymarin were found to inhibit MRP1-, MRP4- and MRP5-mediated transport from intact cells with high affinity. Quercetin ATP binding cassette subfamily C member 1 Homo sapiens
3 Collectively, these results suggest that dietary flavonoids such as quercetin and silymarin can modulate transport activities of MRP1, -4 and -5. Quercetin ATP binding cassette subfamily C member 1 Homo sapiens