Pub. Date : 2005 Aug 31
PMID : 16155407
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The efficacy of DFO at inducing CCL20 mRNA was also observed in human PBMCs and in THP-1 cells, but not in human umbilical vein endothelial cells. | Deferoxamine | C-C motif chemokine ligand 20 | Homo sapiens |
| 2 | Interestingly, unlike other proinflammatory cytokines, such as TNF-alpha and IL-1beta, a time-dependent experiment revealed that DFO slowly induces CCL20, suggesting a novel mechanism of action. | Deferoxamine | C-C motif chemokine ligand 20 | Homo sapiens |
| 3 | A pharmacologic study also revealed that multiple signaling pathways are differentially involved in CCL20 production by DFO, while some of those pathways are not involved in TNF-alpha-induced CCL20 production. | Deferoxamine | C-C motif chemokine ligand 20 | Homo sapiens |