Title : Amplification loop cascade for increasing caspase activity induced by docetaxel.

Pub. Date : 2005 Nov 1

PMID : 16149076






1 Functional Relationships(s)
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1 It is thus conferred that such sequent events as ROS production, caspase activation, JNK/SAPK activation, bcl-2 phosphorylation and the further generation of ROS should be parts of an amplification loop to increase caspase activity, thereby facilitating the apoptotic cell death process. Reactive Oxygen Species mitogen-activated protein kinase 8 Homo sapiens