Pub. Date : 2005 Sep 1
PMID : 16140974
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Adverse effect of adjuvant tamoxifen in premenopausal breast cancer with cyclin D1 gene amplification. | Tamoxifen | cyclin D1 | Homo sapiens |
| 2 | Consequently, a highly significant interaction between tamoxifen treatment and CCND1 amplification could be shown regarding both recurrence-free survival (RR, 6.38; 95% CI, 2.29-17.78; P < 0.001) and overall survival (RR, 5.34; 95% CI, 1.84-15.51; P = 0.002), suggesting an agonistic effect of tamoxifen in ER-positive tumors. | Tamoxifen | cyclin D1 | Homo sapiens |
| 3 | Consequently, a highly significant interaction between tamoxifen treatment and CCND1 amplification could be shown regarding both recurrence-free survival (RR, 6.38; 95% CI, 2.29-17.78; P < 0.001) and overall survival (RR, 5.34; 95% CI, 1.84-15.51; P = 0.002), suggesting an agonistic effect of tamoxifen in ER-positive tumors. | Tamoxifen | cyclin D1 | Homo sapiens |
| 4 | In summary, our data implicate that despite a significant correlation to cyclin D1 protein expression, amplification status of the CCND1 gene seems a strong independent predictor of tamoxifen response, and possibly agonism, in premenopausal breast cancer. | Tamoxifen | cyclin D1 | Homo sapiens |