Title : Punica granatum L. extract inhibits IL-1beta-induced expression of matrix metalloproteinases by inhibiting the activation of MAP kinases and NF-kappaB in human chondrocytes in vitro.

Pub. Date : 2005 Sep

PMID : 16140882






5 Functional Relationships(s)
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1 PFE inhibited the IL-1beta-induced proteoglycan breakdown in cartilage explants in vitro. Coconut Oil interleukin 1 beta Homo sapiens
2 At the cellular level, PFE (6.25-25 mg/L) inhibited the IL-1beta-induced expression of MMP-1, -3, and -13 protein in the medium (P < 0.05) and this was associated with the inhibition of mRNA expression. Coconut Oil interleukin 1 beta Homo sapiens
3 IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay. Coconut Oil interleukin 1 beta Homo sapiens
4 IL-1beta-induced phosphorylation of p38-MAPK, but not that of c-Jun-N-terminal kinase or extracellular regulated kinase, was most susceptible to inhibition by low doses of PFE, and the addition of PFE blocked the activity of p38-MAPK in a kinase activity assay. Coconut Oil interleukin 1 beta Homo sapiens
5 PFE also inhibited the IL-1beta-induced phosphorylation of IkappaBalpha and the DNA binding activity of the transcription factor NF-kappaB in OA chondrocytes. Coconut Oil interleukin 1 beta Homo sapiens