Pub. Date : 2005 Dec 15
PMID : 16137816
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The aim of this study was to evaluate, in a Caco-2 cell line, the effect of a coexposure to 3-methylcholanthrene (3MC, AhR ligand) and WY-14643 (WY, PPARalpha ligand) on CYP1A1 expression (enzymatic activity, mRNA level and promoter activity). | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 2 | An additive effect on CYP1A1 expression was shown in cells coexposed with 3MC (0.1 or 1 microM) and a low WY concentration (30 microM) whereas a potentiating effect was observed after coexposure with 3MC (0.1 or 1 microM) and a high WY concentration (200 microM). | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |
| 3 | In conclusion, coexposure with 3MC and the PPARalpha agonist WY leads to an additive or potentiating effect on CYP1A1 inducibility, depending on the WY concentration. | Methylcholanthrene | cytochrome P450 family 1 subfamily A member 1 | Homo sapiens |