Title : Cyclic induction of senescence with intermittent AZT treatment accelerates both apoptosis and telomere loss.

Pub. Date : 2005 Oct

PMID : 16132531






2 Functional Relationships(s)
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1 Of the telomerase subunits, telomerase reverse transcriptase (hTERT) and c-Myc were the first to show a reduction in activity after AZT treatment, followed by changes in hTER , Mad1 and hTEP-1. Zidovudine MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 CONCLUSION: Cyclic treatment with AZT initially suppressed hTERT and c-Myc, followed by suppression of hTER, Mad1 and hTEP-1. Zidovudine MYC proto-oncogene, bHLH transcription factor Homo sapiens