Title : Hemolytic uremic syndrome-associated Shiga toxins promote endothelial-cell secretion and impair ADAMTS13 cleavage of unusually large von Willebrand factor multimers.

Pub. Date : 2005 Dec 15

PMID : 16131569






1 Functional Relationships(s)
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1 The rate of ULVWF-platelet string cleavage by plasma or recombinant ADAMTS13 was delayed by 3 to 10 minutes (or longer) in the presence of 10 nM Stx-1 or Stx-2 compared with 20 mM histamine. Histamine ADAM metallopeptidase with thrombospondin type 1 motif 13 Homo sapiens