Pub. Date : 2005
PMID : 16127286
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | OBJECTIVE: Since the p53 gene has been identified as a determinant of response to chemotherapy in ovarian carcinoma in previous studies, we investigated the significance of the p53 status in response to topotecan as second-line therapy. | Topotecan | tumor protein p53 | Homo sapiens |
| 2 | RESULTS: Wild-type p53 tumors responsive to first-line therapy maintained substantial responsiveness to topotecan. | Topotecan | tumor protein p53 | Homo sapiens |
| 3 | This outcome is consistent with the clinical observation that the efficacy of topotecan in the treatment of relapsed ovarian carcinoma patients is dependent on platinum sensitivity, because platinum-sensitive tumors are expected to carry wild-type p53. | Topotecan | tumor protein p53 | Homo sapiens |