Pub. Date : 2005 Oct 28
PMID : 16123043
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Src kinase activates endothelial nitric-oxide synthase by phosphorylating Tyr-83. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 2 | The endothelial nitric-oxide synthase (eNOS) is regulated in part by serine/threonine phosphorylation, but eNOS tyrosine phosphorylation is less well understood. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 3 | In the present study we have examined the tyrosine phosphorylation of eNOS in bovine aortic endothelial cells (BAECs) exposed to oxidant stress. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 4 | Hydrogen peroxide and pervanadate (PV) treatment stimulates eNOS tyrosine phosphorylation in BAECs. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 5 | Domain mapping and site-directed mutagenesis studies in COS-7 cells transfected with either eNOS alone and then treated with PV or cotransfected with eNOS and constitutively active v-Src identified Tyr-83 (bovine sequence) as the major eNOS tyrosine phosphorylation site. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 6 | Domain mapping and site-directed mutagenesis studies in COS-7 cells transfected with either eNOS alone and then treated with PV or cotransfected with eNOS and constitutively active v-Src identified Tyr-83 (bovine sequence) as the major eNOS tyrosine phosphorylation site. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 7 | Domain mapping and site-directed mutagenesis studies in COS-7 cells transfected with either eNOS alone and then treated with PV or cotransfected with eNOS and constitutively active v-Src identified Tyr-83 (bovine sequence) as the major eNOS tyrosine phosphorylation site. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 8 | Taken together, these data indicate that Src-mediated tyrosine phosphorylation of eNOS at Tyr-83 modulates eNOS activity in endothelial cells. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 9 | Taken together, these data indicate that Src-mediated tyrosine phosphorylation of eNOS at Tyr-83 modulates eNOS activity in endothelial cells. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 10 | Taken together, these data indicate that Src-mediated tyrosine phosphorylation of eNOS at Tyr-83 modulates eNOS activity in endothelial cells. | Tyrosine | nitric oxide synthase 3 | Bos taurus |
| 11 | Taken together, these data indicate that Src-mediated tyrosine phosphorylation of eNOS at Tyr-83 modulates eNOS activity in endothelial cells. | Tyrosine | nitric oxide synthase 3 | Bos taurus |