Title : Perindopril regulates beta-agonist-induced cardiac apoptosis.

Pub. Date : 2005 Sep

PMID : 16116328






4 Functional Relationships(s)
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1 The effect of short-term beta-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin I-converting enzyme (ACE) activity and its association with the development of cardiac apoptosis was investigated. Isoproterenol angiotensin I converting enzyme Homo sapiens
2 The effect of short-term beta-adrenergic stimulation by isoproterenol on the activity of plasma, lung, and left ventricular (LV) angiotensin I-converting enzyme (ACE) activity and its association with the development of cardiac apoptosis was investigated. Isoproterenol angiotensin I converting enzyme Homo sapiens
3 In addition, LV and plasma ACE activities increased markedly with isoproterenol over the study period up to 5 days. Isoproterenol angiotensin I converting enzyme Homo sapiens
4 The administration of perindopril (an ACE inhibitor) prevented the observed increase in bax and bcl-XS levels and attenuated (50% decrease, P<0.05) the effect of isoproterenol on DNA fragmentation. Isoproterenol angiotensin I converting enzyme Homo sapiens