Title : HIV impairs TNF-alpha release in response to Toll-like receptor 4 stimulation in human macrophages in vitro.

Pub. Date : 2005 Dec

PMID : 16109884






1 Functional Relationships(s)
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1 Recognizing the critical role of Toll-like receptor (TLR) signaling in host defense, this study showed that human U937 macrophage stimulation by the TLR4-specific ligand, lipid A (biologically active component of bacterial LPS), promoted TNF-alpha release through extracellular regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase phosphorylation. Lipid A toll like receptor 4 Homo sapiens