Title : Phosphorylation of interleukin-6 at serine54: an early event in the secretory pathway in human fibroblasts.

Pub. Date : 1992 Jun 15

PMID : 1610348






2 Functional Relationships(s)
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1 When IL-1 alpha-induced fibroblasts were exposed to cycloheximide there was enhancement of the net de novo synthesis and secretion of IL-6 as followed by [35S]-methionine labeling ("superinduction") but the secreted cytokine was no longer phosphorylated as monitored by [32P] labeling. Cycloheximide interleukin 6 Homo sapiens
2 Furthermore, IL-6 phosphorylation is inhibited by cycloheximide through a mechanism different from the drug"s effects on polypeptide synthesis per se. Cycloheximide interleukin 6 Homo sapiens