Pub. Date : 2005 Nov
PMID : 16100528
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 2 | Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |
| 3 | 2 In this study, switching the equivalent residue in the human TRPV1 (which has some significant differences with the rat TRPV1) also rendered this channel relatively insensitive to activation by capsaicin and proved critical in determining the receptor"s sensitivity to the putative endovanilloid N-arachidonoyl-dopamine (NADA), suggesting a similar mode of activation for these two agonists. | Capsaicin | transient receptor potential cation channel, subfamily V, member 1 | Rattus norvegicus |