Title : Coffee consumption induces GSTP in plasma and protects lymphocytes against (+/-)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide induced DNA-damage: results of controlled human intervention trials.

Pub. Date : 2005 Dec 11

PMID : 16099480






1 Functional Relationships(s)
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1 The protective effects were attributed to induction of glutathione-S-transferases (GSTs) and aim of the present human study was to find out if coffee causes induction of GSTs and protects against DNA-damage caused by (+/-)-anti-B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), the DNA-reactive metabolite of benzo(a)pyrene. 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide glutathione S-transferase pi 1 Homo sapiens