Title : Functional assessment of multiple P-glycoprotein (P-gp) probe substrates: influence of cell line and modulator concentration on P-gp activity.

Pub. Date : 2005 Nov

PMID : 16093365






1 Functional Relationships(s)
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1 Low concentrations of ketoconazole (1-3 microM) activated the BL-AP Papp of [3H]vinblastine and [3H]digoxin in MDCK-MDR1 cells but not in MDCK-WT or Caco-2 cells. Vinblastine ATP binding cassette subfamily B member 1 Canis lupus familiaris