Title : Modulation of arachidonic acid metabolism and nitric oxide synthesis by garcinol and its derivatives.

Pub. Date : 2006 Feb

PMID : 16093250






2 Functional Relationships(s)
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1 In LPS-stimulated macrophages, garcinol inhibited the phosphorylation of cPLA2 without altering its protein level, and the effect was related to the inhibition of ERK1/2 phosphorylation. garcinol phospholipase A2 group IVA Homo sapiens
2 The results suggest that garcinol modulates arachidonic acid metabolism by blocking the phosphorylation of cPLA2 and decreases iNOS protein level by inhibiting STAT-1 activation. garcinol phospholipase A2 group IVA Homo sapiens