Title : Cyclooxygenase-2 inhibitors reverse chemoresistance phenotype in medullary thyroid carcinoma by a permeability glycoprotein-mediated mechanism.

Pub. Date : 2005 Oct

PMID : 16091477






1 Functional Relationships(s)
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1 Our data show that TT cells express both MDR1 and COX-2 and that rofecoxib, a selective COX-2 inhibitor, sensitizes TT cells to the cytotoxic effects of doxorubicin, reducing P-gp expression and function. rofecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens