Title : ACE inhibition lowers angiotensin-II-induced monocyte adhesion to HUVEC by reduction of p65 translocation and AT 1 expression.

Pub. Date : 2005 Sep-Oct

PMID : 16088213






3 Functional Relationships(s)
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1 We analyzed the effect of the ACE inhibitor ramiprilat on AngII-dependent cell adhesion molecule (CAM) expression and adhesion of monocytic THP-1 cells to endothelial cells. ramiprilat angiotensinogen Homo sapiens
2 Ramiprilat reduced AT 1 expression on endothelial cells and decreased the AngII-induced p65 translocation into the nucleus. ramiprilat angiotensinogen Homo sapiens
3 Thus, modulation of the local AngII system by ramiprilat may at least in part contribute to the benefits of ACE inhibition in the treatment of atherosclerotic diseases. ramiprilat angiotensinogen Homo sapiens