Title : Associations between drug metabolism genotype, chemotherapy pharmacokinetics, and overall survival in patients with breast cancer.

Pub. Date : 2005 Sep 1

PMID : 16087946






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Patients having a variant genotype of cytochrome P450 3A4 displayed higher blood concentrations of parent (inactive) cyclophosphamide with the second and third doses (P = .024 and .028, respectively) in addition to slower cyclophosphamide activation over the three doses (P = .031). Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens
2 Patients having a variant genotype of cytochrome P450 3A4 displayed higher blood concentrations of parent (inactive) cyclophosphamide with the second and third doses (P = .024 and .028, respectively) in addition to slower cyclophosphamide activation over the three doses (P = .031). Cyclophosphamide cytochrome P450 family 3 subfamily A member 4 Homo sapiens