Title : Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model.

Pub. Date : 2005 Aug 16

PMID : 16087879






1 Functional Relationships(s)
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1 We found that PC12 cells expressing polyglutamine-expanded huntingtin exon 1 accumulated less mutant protein and showed decreased cell death when treated with clioquinol. polyglutamine huntingtin Rattus norvegicus