Title : Methylguanine methyltransferase activity deficiency in immature rat mammary epithelial cells parallels increased carcinogenic susceptibility.

Pub. Date : 2005 Nov

PMID : 16086375






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Inhibition of methylguanine methyltransferase (MGMT) did not affect immature MECs but caused mature MECs to recapitulate the immature response to NMU. Methylnitrosourea O-6-methylguanine-DNA methyltransferase Rattus norvegicus
2 Inhibition of methylguanine methyltransferase (MGMT) did not affect immature MECs but caused mature MECs to recapitulate the immature response to NMU. Methylnitrosourea O-6-methylguanine-DNA methyltransferase Rattus norvegicus
3 Immature kidneys, which preferentially developed nephroblastomas after NMU treatment, also displayed significantly lower MGMT activity than mature kidneys. Methylnitrosourea O-6-methylguanine-DNA methyltransferase Rattus norvegicus