Title : Synthesis and evaluation of dopamine D3 receptor antagonist 11C-GR218231 as PET tracer for P-glycoprotein.

Pub. Date : 2005 Aug

PMID : 16085598






3 Functional Relationships(s)
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1 To demonstrate the influence of P-glycoprotein on cerebral uptake of (11)C-GR218231, the efflux pump was modulated with 50 mg/kg cyclosporine A. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
2 Modulation of P-glycoprotein with cyclosporine A caused a 12-fold higher (11)C-GR218231 uptake in the brain, indicating that the low cerebral tracer uptake was caused by the P-glycoprotein efflux pump in the blood-brain barrier. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus
3 Modulation of P-glycoprotein with cyclosporine A caused a 12-fold higher (11)C-GR218231 uptake in the brain, indicating that the low cerebral tracer uptake was caused by the P-glycoprotein efflux pump in the blood-brain barrier. Cyclosporine ATP-binding cassette, subfamily B (MDR/TAP), member 1B Rattus norvegicus