Pub. Date : 2005
PMID : 16082080
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that combining low-dose FK506 with anti-CD40 Ligand (anti-CD40L mAb) would enhance regeneration through peripheral nerve allografts while preserving immune unresponsiveness. | Tacrolimus | CD40 ligand | Mus musculus |
| 2 | RESULTS: Animals receiving low-dose FK506 with anti-CD40L mAb exhibited robust nerve regeneration comparable to the isograft and high-dose FK506 allograft groups. | Tacrolimus | CD40 ligand | Mus musculus |
| 3 | Nerve density was significantly increased in the low-dose FK506 with anti-CD40L mAb group compared to animals receiving anti-CD40L mAb alone (p < 0.05). | Tacrolimus | CD40 ligand | Mus musculus |
| 4 | CONCLUSION: When combined with anti-CD40L mAb, low-dose FK506 enhances nerve regeneration without disrupting immune unresponsiveness. | Tacrolimus | CD40 ligand | Mus musculus |