Title : Curcumin suppresses interleukin 1beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways.

Pub. Date : 2005 Nov

PMID : 16081677






2 Functional Relationships(s)
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Protein Name
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1 Curcumin suppressed cytokine-induced mPGES-1 by inhibiting phosphorylation of Jun N-terminal kinase (JNK)1/2. Curcumin mitogen-activated protein kinase 8 Homo sapiens
2 These results indicate that curcumin inhibits IL-1beta-induced PGE(2) formation by inhibiting the expression of mPGES-1 that is mediated by suppression of EGR-1 expression as well as NF-kappaB and JNK1/2. Curcumin mitogen-activated protein kinase 8 Homo sapiens