Title : Janus kinase 2 enhances the stability of the mature growth hormone receptor.

Pub. Date : 2005 Nov

PMID : 16081639






1 Functional Relationships(s)
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1 Cycloheximide chase experiments with metalloprotease, proteasome, and lysosome inhibitors indicated that the enhanced stability of mature GHR conferred by JAK2 is not related to effects on constitutive receptor metalloproteolysis but rather is a result of reduced constitutive endosomal/lysosomal degradation of the mature GHR. Cycloheximide Janus kinase 2 Homo sapiens