Title : A quantitative assessment of the significance of molecular mobility as a determinant for the stability of lyophilized insulin formulations.

Pub. Date : 2005 Aug

PMID : 16078146






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1 The temperature- and Tg-dependence of the degradation rate indicated that the reactivity of insulin in the trehalose formulation is affected by molecular mobility at low humidity (12% RH), such that the ratio of the observed rate constant (k") to the rate constant governed only by the activational barrier (k) was 0.051 at the Tg. Rhodium insulin Homo sapiens