Title : Poorly specific binding of thyroglobulin to orbital fibroblasts from patients with Graves' ophthalmopathy.

Pub. Date : 2005 May

PMID : 16075925






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Biotin-labeled Tg bound to both skin and orbital fibroblasts in a saturable manner, with constants of dissociation of approximately 75 nmol/l for skin fibroblasts and approximately 40 nmol/I for orbital fibroblasts. Biotin thyroglobulin Homo sapiens
2 In an attempt to identify Tg binding sites, fibroblast extracts were blotted onto membranes that were incubated with biotin-labeled Tg, which bound especially to a protein migrating at approximately 300 kDa, present in both orbital and skin fibroblast extracts. Biotin thyroglobulin Homo sapiens
3 In an attempt to identify Tg binding sites, fibroblast extracts were blotted onto membranes that were incubated with biotin-labeled Tg, which bound especially to a protein migrating at approximately 300 kDa, present in both orbital and skin fibroblast extracts. Biotin thyroglobulin Homo sapiens