Title : TRPV1 activation results in disruption of the blood-brain barrier in the rat.

Pub. Date : 2005 Oct

PMID : 16056236






2 Functional Relationships(s)
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1 The TRPV1 antagonist capsazepine (1 mM) reduced the response to capsaicin (100 microM), from 1.78+/-0.15 to 0.63+/-0.10 (n = 4). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus
2 The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1). Capsaicin transient receptor potential cation channel, subfamily V, member 1 Rattus norvegicus