Title : Statins and nitric oxide reduce C-reactive protein production while inflammatory conditions persist.

Pub. Date : 2006 Mar

PMID : 16054696






2 Functional Relationships(s)
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1 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Simvastatin interleukin 6 Homo sapiens
2 Here, we show that pravastatin and simvastatin prevent the induction of CRP expression in human hepatoma Hep3B cells exposed to proinflammatory cytokines IL-6 and IL-1beta The nitric oxide (NO) donor, sodium nitroprusside, also prevented the induction of CRP expression while the CRP inducers IL-6 and IL-1beta were present with the cells. Simvastatin interleukin 6 Homo sapiens