Title : Simvastatin reduces caspase-3 activation and inflammatory markers induced by hypoxia-ischemia in the newborn rat.

Pub. Date : 2006 Jan

PMID : 16054375






1 Functional Relationships(s)
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1 Poly (ADP-ribose) polymerase fragmentation, caspase-1 activation, and IL-1beta and ICAM-1 mRNA expression were increased by hypoxia-ischemia and significantly reduced in simvastatin-treated animals. Simvastatin intercellular adhesion molecule 1 Rattus norvegicus