Pub. Date : 2006 Jan 15
PMID : 16052517
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Oh8dG induces G1 arrest in a human acute leukemia cell line by upregulating P21 and blocking the RAS to ERK signaling pathway. | 8-ohdg | H3 histone pseudogene 16 | Homo sapiens |
| 2 | Simultaneously, oh8dG-treated KG-1 showed an increase in the oh8Gua content of DNA, upregulation of p21 (an inhibitor of cdk), and Ras inactivation. | 8-ohdg | H3 histone pseudogene 16 | Homo sapiens |
| 3 | We report that oh8dG induces the arrest of KG-1 growth at the G1 phase mainly by upregulating p21 and inactivating Ras. | 8-ohdg | H3 histone pseudogene 16 | Homo sapiens |