Title : ERK1/2 and MEK1/2 induced by Kaposi's sarcoma-associated herpesvirus (human herpesvirus 8) early during infection of target cells are essential for expression of viral genes and for establishment of infection.

Pub. Date : 2005 Aug

PMID : 16051824






2 Functional Relationships(s)
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1 Analyses of viral gene expression by quantitative real-time reverse transcriptase PCR revealed that pretreatment of cells with U0126 for 1 h and during the 2-h infection with KSHV significantly inhibited the expression of ORF 73, ORF 50 (RTA), and the IE-K8 and v-IRF2 genes. U 0126 LANA Human gammaherpesvirus 8
2 Expression of ORF 73 in BCBL-1 cells was also significantly inhibited by preincubation with U0126. U 0126 LANA Human gammaherpesvirus 8