Title : Adhesion and Rac1-dependent regulation of biglycan gene expression by transforming growth factor-beta. Evidence for oxidative signaling through NADPH oxidase.

Pub. Date : 2005 Sep 30

PMID : 16051607






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Like Rac1-T17N, the NADPH oxidase inhibitor diphenylene iodonium and the tyrosine kinase inhibitor herbimycin A blocked TGF-beta-induced p38 activation and BGN expression, suggesting that Rac1 exerts its effect on BGN and p38 through increasing NADPH oxidase activity and subsequent production of reactive oxygen species. diphenyleneiodonium transforming growth factor beta 1 Homo sapiens