Title : Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes.

Pub. Date : 2006 Mar 15

PMID : 16051293






3 Functional Relationships(s)
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1 Structure-activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes. Pyrethrins sodium voltage-gated channel alpha subunit 10 Rattus norvegicus
2 This paper describes the action of 11 structurally diverse commercial pyrethroid insecticides on the rat Na v 1.8 sodium channel isoform, the principal carrier of the tetrodotoxin-resistant, pyrethroid-sensitive sodium current of sensory neurons, expressed in Xenopus laevis oocytes. Pyrethrins sodium voltage-gated channel alpha subunit 10 Rattus norvegicus
3 The selective expression of Na v 1.8 sodium channels in nociceptive neurons suggests that these channels may be important targets for pyrethroids in the production of paresthesia following dermal exposure. Pyrethrins sodium voltage-gated channel alpha subunit 10 Rattus norvegicus