Title : A novel adenosine analog, thio-Cl-IB-MECA, induces G0/G1 cell cycle arrest and apoptosis in human promyelocytic leukemia HL-60 cells.

Pub. Date : 2005 Sep 15

PMID : 16051194






1 Functional Relationships(s)
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1 On this line, we recently found that a novel adenosine analog, 2-chloro-N6-(3-iodobenzyl)-4"-thioadenosine-5"-N-methyluronamide (thio-Cl-IB-MECA) was a potent human A3AR agonist, and is superior to a known agonist Cl-IB-MECA [Jeong LS, Jin DZ, Kim HO, Shin DH, Moon HR, Gunaga P, et al. 2-chloro-N(6)-(3-iodobenzyl)adenosine-5'-N-methyluronamide adenosine A3 receptor Homo sapiens