Title : Regulation of testis-specific carnitine transporter (octn3) gene by proximal cis-acting elements Sp1 in mice.

Pub. Date : 2005 Sep 15

PMID : 16051193






4 Functional Relationships(s)
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1 The gene products octn2 and octn3, which transport carnitine with high affinity, are both expressed in testis, where carnitine is required to maintain sperm cell motility. Carnitine solute carrier family 22 (organic cation transporter), member 21 Mus musculus
2 The gene products octn2 and octn3, which transport carnitine with high affinity, are both expressed in testis, where carnitine is required to maintain sperm cell motility. Carnitine solute carrier family 22 (organic cation transporter), member 21 Mus musculus
3 Furthermore, the expressions of both of octn2 and octn3 genes in TM4 cells were up-regulated by palmitic acid, whereas carnitine increased only the expression of octn2 without any change in octn3 expression. Carnitine solute carrier family 22 (organic cation transporter), member 21 Mus musculus
4 Accordingly, the expressions of octn2 and 3 are regulated by distinct mechanisms, suggesting distinct roles of octn2 and octn3 in carnitine transport. Carnitine solute carrier family 22 (organic cation transporter), member 21 Mus musculus