Title : STAT3-mediated transcription of Bcl-2, Mcl-1 and c-IAP2 prevents apoptosis in polyamine-depleted cells.

Pub. Date : 2005 Dec 1

PMID : 16048438






4 Functional Relationships(s)
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1 Polyamine depletion by DFMO (alpha-difluoromethylornithine) caused phosphorylation of STAT3 at Tyr-705 and Ser-727. Eflornithine signal transducer and activator of transcription 3 Homo sapiens
2 Polyamine depletion by DFMO (alpha-difluoromethylornithine) caused phosphorylation of STAT3 at Tyr-705 and Ser-727. Eflornithine signal transducer and activator of transcription 3 Homo sapiens
3 Expression of DN-STAT3 (dominant negative-STAT3) completely eliminated the protective effect of DFMO against TNF-alpha-induced apoptosis. Eflornithine signal transducer and activator of transcription 3 Homo sapiens
4 Expression of DN-STAT3 (dominant negative-STAT3) completely eliminated the protective effect of DFMO against TNF-alpha-induced apoptosis. Eflornithine signal transducer and activator of transcription 3 Homo sapiens