Title : Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome.

Pub. Date : 2005 Aug

PMID : 16045972






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1 To test this hypothesis, we evaluated the effects of chronic donepezil, nicotine and haloperidol on expression levels of 5-HT2A mRNA and 5-HT2A receptor density in select brain regions. Haloperidol 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
2 To test this hypothesis, we evaluated the effects of chronic donepezil, nicotine and haloperidol on expression levels of 5-HT2A mRNA and 5-HT2A receptor density in select brain regions. Haloperidol 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
3 In the frontal cortex, only haloperidol significantly reduced the 5-HT2A receptor density. Haloperidol 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
4 The cortex was the only area where donepezil, nicotine and haloperidol significantly reduced the 5-HT2A receptor density. Haloperidol 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus
5 The results suggest that the anti-tic properties of donepezil, nicotine and haloperidol in this paradigm might be due to antagonism of cortical 5-HT2A receptors. Haloperidol 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus