Title : Coadministration of gemfibrozil and itraconazole has only a minor effect on the pharmacokinetics of the CYP2C9 and CYP3A4 substrate nateglinide.

Pub. Date : 2005 Aug

PMID : 16042675






1 Functional Relationships(s)
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1 Our aim was to investigate the effects of the gemfibrozil-itraconazole combination on the pharmacokinetics and pharmacodynamics of another meglitinide analogue, nateglinide, which is metabolized by CYP2C9 and CYP3A4. Nateglinide cytochrome P450 family 2 subfamily C member 9 Homo sapiens