Pub. Date : 2005 Sep 9
PMID : 16039613
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Constitutive overexpression of the Hsp70 molecular chaperone is capable of suppressing polyglutamine neurodegeneration. | polyglutamine | Heat-shock-protein-70Ab | Drosophila melanogaster |
| 2 | We further showed that cellular heat shock response remained intact in aged flies, indicating the decline of Hsp70 levels observed in polyglutamine-expressing flies is not due to normal ageing. | polyglutamine | Heat-shock-protein-70Ab | Drosophila melanogaster |
| 3 | In contrast to the well-documented polyglutamine suppression caused by constitutive Hsp70 overexpression, no suppression of degeneration was observed when inducible copies of hsp70 transgenes were instead coexpressed. | polyglutamine | Heat-shock-protein-70Ab | Drosophila melanogaster |
| 4 | This supports a transcriptional dysregulation of endogenous hsp70 gene induction in polyglutamine flies. | polyglutamine | Heat-shock-protein-70Ab | Drosophila melanogaster |