Title : Production of IL-1beta, hydrogen peroxide, and nitric oxide by colonic mucosa decreases sigmoid smooth muscle contractility in ulcerative colitis.

Pub. Date : 2005 Dec

PMID : 16033908






1 Functional Relationships(s)
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1 We have previously shown that sigmoid circular muscle cells from patients with ulcerative colitis (UC) exhibit reduced contraction and Ca2+ signaling in response to the neurotransmitter neurokinin A (NKA) and that IL-1beta and H2O2 may contribute to these reduced responses in UC. Hydrogen Peroxide tachykinin precursor 1 Homo sapiens