Pub. Date : 2005 Jul 15
PMID : 16024639
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In this study, we showed that tunicamycin, a naturally occurring antibiotic, is a potent enhancer of TRAIL-induced apoptosis through up-regulation of DR5 expression. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 2 | Tunicamycin significantly sensitized PC-3, androgen-independent human prostate cancer cells, to TRAIL-induced apoptosis. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 3 | The tunicamycin-mediated enhancement of TRAIL-induced apoptosis was markedly blocked by a recombinant human DR5/Fc chimeric protein. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |
| 4 | Furthermore, the tunicamycin-mediated sensitization to TRAIL was efficiently reduced by DR5 small interfering RNA, suggesting that the sensitization was mediated through induction of DR5 expression. | Tunicamycin | TNF superfamily member 10 | Homo sapiens |