Pub. Date : 2005 Jul
PMID : 16014854
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Response of Plasmodium falciparum to cotrimoxazole therapy: relationship with plasma drug concentrations and dihydrofolate reductase and dihydropteroate synthase genotypes. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |
| 2 | We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |
| 3 | We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |
| 4 | We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |
| 5 | We assessed the efficacy of trimethoprim/sulfamethoxazole (TRM/SMX) in vivo in relation to the frequency of dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) alleles in 45 Sudanese malaria patients. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |
| 6 | However, the presence of the triple mutant dhfr (Ile-51/Arg-59/Asn-108) with the dhps Gly-437 genotype in all recurring infections, suggests the importance of codon 59 and 437 alleles in susceptibility to TRM/SMX. | Trimethoprim, Sulfamethoxazole Drug Combination | dihydrofolate reductase | Homo sapiens |