Pub. Date : 2005 May
PMID : 16012077
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The formation of 4-hydroxyestazolam from estazolam in pooled human liver microsomes was significantly inhibited by itraconazole and erythromycin, specific CYP3A4 inhibitors, in a dose-dependent manner, with IC50 values of 1.1 and 12.8 microM, respectively. | 4-Hydroxy Estazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |
| 2 | In conclusion, the biotransformation of estazolam to 4-hydroxyestazolam was catalyzed by CYP3A4. | 4-Hydroxy Estazolam | cytochrome P450 family 3 subfamily A member 4 | Homo sapiens |