Title : The role of hydrogen bond acceptor groups in the interaction of substrates with Pdr5p, a major yeast drug transporter.

Pub. Date : 2005 Jul 19

PMID : 16008355






1 Functional Relationships(s)
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1 In this study, we use a combination of whole cell transport assays and photoaffinity labeling of Pdr5p with [(125)I]iodoarylazidoprazosin in purified plasma membrane vesicles to study the behavior of two series of novel substrates: trityl (triphenylmethyl) and carbazole derivatives. azidoprazosin ATP-binding cassette multidrug transporter PDR5 Saccharomyces cerevisiae S288C